[HTML][HTML] N-glycosylation of the I-like domain of β1 integrin is essential for β1 integrin expression and biological function: identification of the minimal N-glycosylation …
T Isaji, Y Sato, T Fukuda, J Gu - Journal of biological chemistry, 2009 - ASBMB
N-Glycosylation of integrin α5β1 plays a crucial role in cell spreading, cell migration, ligand
binding, and dimer formation, but the detailed mechanisms by which N-glycosylation
mediates these functions remain unclear. In a previous study, we showed that three potential
N-glycosylation sites (α5S3–5) on the β-propeller of the α5 subunit are essential to the
functional expression of the subunit. In particular, site 5 (α5S5) is the most important for its
expression on the cell surface. In this study, the function of the N-glycans on the integrin β1 …
binding, and dimer formation, but the detailed mechanisms by which N-glycosylation
mediates these functions remain unclear. In a previous study, we showed that three potential
N-glycosylation sites (α5S3–5) on the β-propeller of the α5 subunit are essential to the
functional expression of the subunit. In particular, site 5 (α5S5) is the most important for its
expression on the cell surface. In this study, the function of the N-glycans on the integrin β1 …