Cross-talk between integrin-mediated adhesion and growth factors has been described in
many recent studies; however, the underlying mechanisms remain incompletely understood.
We report here that detachment of cells from the extracellular matrix induced a decrease in
both the autophosphorylation and protein levels of the platelet-derived growth factor
receptor β (PDGF-R β), which was completely reversed upon replating cells on fibronectin.
The effect occurred in all cells examined but to a greater extent in primary fibroblasts …