Angiopoietin-2 is increased in severe sepsis: correlation with inflammatory mediators
SE Orfanos, A Kotanidou, C Glynos… - Critical care …, 2007 - journals.lww.com
Objective: Angiopoietin (Ang)-2 is an endothelium-specific growth factor, regulated by
proinflammatory stimuli, that destabilizes vascular endothelium and increases vascular
leakage; consequently, Ang-2 may contribute to sepsis pathophysiology. We have studied 1)
serum Ang-2 levels in critically-ill patients and investigated potential relationships with
inflammatory mediators and indices of disease severity and 2) the effect of sepsis-related
inflammatory mediators on Ang-2 production by lung endothelium in vitro. Design …
proinflammatory stimuli, that destabilizes vascular endothelium and increases vascular
leakage; consequently, Ang-2 may contribute to sepsis pathophysiology. We have studied 1)
serum Ang-2 levels in critically-ill patients and investigated potential relationships with
inflammatory mediators and indices of disease severity and 2) the effect of sepsis-related
inflammatory mediators on Ang-2 production by lung endothelium in vitro. Design …