Type 1 diabetes

MA Atkinson, GS Eisenbarth, AW Michels - The lancet, 2014 - thelancet.com
MA Atkinson, GS Eisenbarth, AW Michels
The lancet, 2014thelancet.com
Over the past decade, knowledge of the pathogenesis and natural history of type 1 diabetes
has grown substantially, particularly with regard to disease prediction and heterogeneity,
pancreatic pathology, and epidemiology. Technological improvements in insulin pumps and
continuous glucose monitors help patients with type 1 diabetes manage the challenge of
lifelong insulin administration. Agents that show promise for averting debilitating disease-
associated complications have also been identified. However, despite broad organisational …
Summary
Over the past decade, knowledge of the pathogenesis and natural history of type 1 diabetes has grown substantially, particularly with regard to disease prediction and heterogeneity, pancreatic pathology, and epidemiology. Technological improvements in insulin pumps and continuous glucose monitors help patients with type 1 diabetes manage the challenge of lifelong insulin administration. Agents that show promise for averting debilitating disease-associated complications have also been identified. However, despite broad organisational, intellectual, and fiscal investments, no means for preventing or curing type 1 diabetes exists, and, globally, the quality of diabetes management remains uneven. This Seminar discusses current progress in epidemiology, pathology, diagnosis, and treatment of type 1 diabetes, and prospects for an improved future for individuals with this disease.
thelancet.com