Intraoperative identification of sentinel lymph nodes by near-infrared fluorescence imaging in patients with breast cancer

N Tagaya, R Yamazaki, A Nakagawa, A Abe… - The American Journal of …, 2008 - Elsevier
We present a novel method for sentinel lymph node (SLN) identification by fluorescence
imaging that provides a high detection rate and a low false-negativity rate. Twenty-five
breast cancer patients with tumors less than 3 cm in diameter were enrolled. A combination
of indocyanine green and indigo carmine was injected subdermally in the areola.
Subcutaneous lymphatic channels draining from the areola to the axilla were immediately
showed by fluorescence imaging. After incising the axillary skin near the point of …