Update on epigenetics in allergic disease

H Harb, H Renz - Journal of Allergy and Clinical Immunology, 2015 - Elsevier
Chronic inflammatory diseases, including allergies and asthma, are the result of complex
gene-environment interactions. One of the most challenging questions in this regard relates
to the biochemical mechanism of how exogenous environmental trigger factors modulate
and modify gene expression, subsequently leading to the development of chronic
inflammatory conditions. Epigenetics comprises the umbrella of biochemical reactions and
mechanisms, such as DNA methylation and chromatin modifications on histones and other …