Targeted reduction of CCR4+ cells is sufficient to suppress allergic airway inflammation
A Honjo, H Ogawa, M Azuma, T Tezuka, S Sone… - Respiratory …, 2013 - Elsevier
Back ground Bronchial asthma is characterized by allergic airway inflammation involving CC
chemokine receptor type 4 (CCR4)-positive Th2 cells. As such, we hypothesize that the
disease can be alleviated by targeted-elimination of CCR4+ cells. Thymus and activation-
regulated chemokine (TARC)-PE38, a TARC fused the exotoxin fragment PE38 from
Pseudomonas aeruginosa, has been shown to efficiently kill CCR4+ cells by delivering the
exotoxin fragment PE38 into CCR4+ cells. To test our hypothesis, we examined whether …
chemokine receptor type 4 (CCR4)-positive Th2 cells. As such, we hypothesize that the
disease can be alleviated by targeted-elimination of CCR4+ cells. Thymus and activation-
regulated chemokine (TARC)-PE38, a TARC fused the exotoxin fragment PE38 from
Pseudomonas aeruginosa, has been shown to efficiently kill CCR4+ cells by delivering the
exotoxin fragment PE38 into CCR4+ cells. To test our hypothesis, we examined whether …
