Role of C/EBP homologous protein and endoplasmic reticulum stress in asthma exacerbation by regulating the IL-4/signal transducer and activator of transcription 6 …

Y Wang, J Zhu, L Zhang, Z Zhang, L He, Y Mou… - Journal of Allergy and …, 2017 - Elsevier
Background C/EBP homologous protein (Chop), a marker of endoplasmic reticulum (ER)
stress, exhibits aberrant expression patterns during asthma development. However, its exact
role in asthma pathogenesis is not fully understood. Objectives We aimed to determine the
function and mechanism of Chop in the pathogenesis of allergic asthma in patients and
animals. Methods Studies were conducted in asthmatic patients and Chop−/− mice to
dissect the role of Chop and ER stress in asthma pathogenesis. An ovalbumin (OVA) …