Alveolar macrophages in allergic asthma: the forgotten cell awakes
C Draijer, M Peters-Golden - Current allergy and asthma reports, 2017 - Springer
C Draijer, M Peters-Golden
Current allergy and asthma reports, 2017•SpringerAbstract Purpose of Review The role of alveolar macrophages in innate immune responses
has long been appreciated. Here, we review recent studies evaluating the participation of
these cells in allergic inflammation. Recent Findings Immediately after allergen exposure,
monocytes are rapidly recruited from the bloodstream and serve to promote acute
inflammation. By contrast, resident alveolar macrophages play a predominantly suppressive
role in an effort to restore homeostasis. As inflammation becomes established after repeated …
has long been appreciated. Here, we review recent studies evaluating the participation of
these cells in allergic inflammation. Recent Findings Immediately after allergen exposure,
monocytes are rapidly recruited from the bloodstream and serve to promote acute
inflammation. By contrast, resident alveolar macrophages play a predominantly suppressive
role in an effort to restore homeostasis. As inflammation becomes established after repeated …
Purpose of Review
The role of alveolar macrophages in innate immune responses has long been appreciated. Here, we review recent studies evaluating the participation of these cells in allergic inflammation.
Recent Findings
Immediately after allergen exposure, monocytes are rapidly recruited from the bloodstream and serve to promote acute inflammation. By contrast, resident alveolar macrophages play a predominantly suppressive role in an effort to restore homeostasis. As inflammation becomes established after repeated exposures, alveolar macrophages can polarize across a continuum of activation phenotypes, losing their suppressive functions and gaining pathogenic functions.
Summary
Future research should focus on the diverse roles of monocytes/macrophages during various types and phases of allergic inflammation. These properties could lead us to new therapeutic opportunities.
Springer