[HTML][HTML] Selenium levels affect the IL-4–induced expression of alternative activation markers in murine macrophages
Selenium (Se), in the form of selenoproteins, imparts many health benefits with
antiinflammatory properties. Previous studies have shown that Se supplementation of
macrophages negatively regulates the LPS-dependent production of inducible NO synthase
(iNOS), a proinflammatory gene. Therefore, we hypothesized that L-arginine, a substrate for
iNOS, is acted upon by arginase-I (Arg-I), contributing to the resolution of inflammation. We
investigated the antiinflammatory activity of Se using LPS and IL-4–treated C57BL/6 murine …
antiinflammatory properties. Previous studies have shown that Se supplementation of
macrophages negatively regulates the LPS-dependent production of inducible NO synthase
(iNOS), a proinflammatory gene. Therefore, we hypothesized that L-arginine, a substrate for
iNOS, is acted upon by arginase-I (Arg-I), contributing to the resolution of inflammation. We
investigated the antiinflammatory activity of Se using LPS and IL-4–treated C57BL/6 murine …