[HTML][HTML] Crescendo skin sympathetic nerve activity and ventricular arrhythmia

RA Kabir, A Doytchinova, X Liu, D Adams… - Journal of the American …, 2017 - jacc.org
RA Kabir, A Doytchinova, X Liu, D Adams, S Straka, LS Chen, C Shen, SF Lin, TH Everett
Journal of the American College of Cardiology, 2017jacc.org
We recently reported a new method (neuECG) to simultaneously record electrocardiogram
(ECG) and skin sympathetic nerve activity (SKNA) in humans (1). There was a significant
association between SKNA and paroxysmal atrial tachyarrhythmias (2). While our
preliminary study showed that ventricular tachycardia (VT) and ventricular fibrillation (VF)
episodes were frequently preceded by elevated SKNA (1), it was unclear if a progressively
increased (crescendo) magnitude of SKNA was needed to trigger ventricular arrhythmias …
We recently reported a new method (neuECG) to simultaneously record electrocardiogram (ECG) and skin sympathetic nerve activity (SKNA) in humans (1). There was a significant association between SKNA and paroxysmal atrial tachyarrhythmias (2). While our preliminary study showed that ventricular tachycardia (VT) and ventricular fibrillation (VF) episodes were frequently preceded by elevated SKNA (1), it was unclear if a progressively increased (crescendo) magnitude of SKNA was needed to trigger ventricular arrhythmias. The purpose of the present study was to test the hypothesis that crescendo SKNA was associated with VT/VF. Written informed consent was obtained from 23 patients to participate in this Institutional Review Board–approved study. Among them, 6 patients (age 50+ 13 years, 4 males) had recurrent VT/VF and analyzable neuECG recordings. Two received amiodarone, 2 received beta-blockers, and the remaining 2 received both. The beta blockers included metoprolol (5 mg intravenously
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