[HTML][HTML] Extracellular protein disulfide isomerase regulates feedback activation of platelet thrombin generation via modulation of coagulation factor binding
K Jurk, J Lahav, H Van Aken, MF Brodde… - Journal of Thrombosis …, 2011 - Elsevier
Background: Protein disulfide isomerase (PDI) controls platelet integrin function, tissue‐
factor (TF) activation, and concentrates at fibrin and thrombus formation sites of vascular
injury. Objective: To investigate the involvement of surface thiol isomerases and especially
PDI, in thrombin‐mediated thrombin amplification on human platelets. Methods/results:
Using a newly developed thrombin‐dependent platelet thrombin generation assay, we
observed that the feedback activation of thrombin generation on the platelet surface does …
factor (TF) activation, and concentrates at fibrin and thrombus formation sites of vascular
injury. Objective: To investigate the involvement of surface thiol isomerases and especially
PDI, in thrombin‐mediated thrombin amplification on human platelets. Methods/results:
Using a newly developed thrombin‐dependent platelet thrombin generation assay, we
observed that the feedback activation of thrombin generation on the platelet surface does …