Involvement of the ERK signaling cascade in protein kinase C-mediated cell cycle arrest in intestinal epithelial cells
JA Clark, AR Black, OV Leontieva, MR Frey… - Journal of Biological …, 2004 - jbc.org
We have reported previously that protein kinase C (PKC) signaling can mediate a program
of cell cycle withdrawal in IEC-18 nontransformed intestinal crypt cells, involving rapid
disappearance of cyclin D1, increased expression of Cip/Kip cyclin-dependent kinase
inhibitors, and activation of the growth suppressor function of pocket proteins (Frey, MR,
Clark, JA, Leontieva, O., Uronis, JM, Black, AR, and Black, JD (2000) J. Cell Biol. 151, 763–
777). In the current study, we present evidence to support a requisite role for PKC α in …
of cell cycle withdrawal in IEC-18 nontransformed intestinal crypt cells, involving rapid
disappearance of cyclin D1, increased expression of Cip/Kip cyclin-dependent kinase
inhibitors, and activation of the growth suppressor function of pocket proteins (Frey, MR,
Clark, JA, Leontieva, O., Uronis, JM, Black, AR, and Black, JD (2000) J. Cell Biol. 151, 763–
777). In the current study, we present evidence to support a requisite role for PKC α in …