Antibody-mediated graft injury: complement-dependent and complement-independent mechanisms
NM Valenzuela, JT McNamara… - Current opinion in organ …, 2014 - journals.lww.com
NM Valenzuela, JT McNamara, EF Reed
Current opinion in organ transplantation, 2014•journals.lww.comThe current literature suggests that, although complement-fixing antibodies may have some
prognostic value for graft outcome, complement-independent mechanisms of graft injury are
increasingly relevant. Therapeutic strategies, which target endothelial activation induced by
antibodies may ameliorate vascular inflammation and mononuclear cell infiltration
characteristic of AMR.
prognostic value for graft outcome, complement-independent mechanisms of graft injury are
increasingly relevant. Therapeutic strategies, which target endothelial activation induced by
antibodies may ameliorate vascular inflammation and mononuclear cell infiltration
characteristic of AMR.
Summary
The current literature suggests that, although complement-fixing antibodies may have some prognostic value for graft outcome, complement-independent mechanisms of graft injury are increasingly relevant. Therapeutic strategies, which target endothelial activation induced by antibodies may ameliorate vascular inflammation and mononuclear cell infiltration characteristic of AMR.
Lippincott Williams & Wilkins