Direct and indirect allograft recognition: pathways dictating graft rejection mechanisms

CM Lin, RG Gill - Current opinion in organ transplantation, 2016 - journals.lww.com
CM Lin, RG Gill
Current opinion in organ transplantation, 2016journals.lww.com
Summary Importantly,'cognate'CD4+ and CD8+ T cells have strikingly similar requirements
for rejection, suggesting that this effector mechanism is dictated by the nature of allograft
recognition rather than by T-cell subset. Conversely,'noncognate'allograft recognition drives
an increasingly appreciated role for inciting innate immunity in mediating allograft injury.
Summary
Importantly,‘cognate’CD4+ and CD8+ T cells have strikingly similar requirements for rejection, suggesting that this effector mechanism is dictated by the nature of allograft recognition rather than by T-cell subset. Conversely,‘noncognate’allograft recognition drives an increasingly appreciated role for inciting innate immunity in mediating allograft injury.
Lippincott Williams & Wilkins