Direct and indirect allograft recognition: pathways dictating graft rejection mechanisms
CM Lin, RG Gill - Current opinion in organ transplantation, 2016 - journals.lww.com
CM Lin, RG Gill
Current opinion in organ transplantation, 2016•journals.lww.comSummary Importantly,'cognate'CD4+ and CD8+ T cells have strikingly similar requirements
for rejection, suggesting that this effector mechanism is dictated by the nature of allograft
recognition rather than by T-cell subset. Conversely,'noncognate'allograft recognition drives
an increasingly appreciated role for inciting innate immunity in mediating allograft injury.
for rejection, suggesting that this effector mechanism is dictated by the nature of allograft
recognition rather than by T-cell subset. Conversely,'noncognate'allograft recognition drives
an increasingly appreciated role for inciting innate immunity in mediating allograft injury.
Summary
Importantly,‘cognate’CD4+ and CD8+ T cells have strikingly similar requirements for rejection, suggesting that this effector mechanism is dictated by the nature of allograft recognition rather than by T-cell subset. Conversely,‘noncognate’allograft recognition drives an increasingly appreciated role for inciting innate immunity in mediating allograft injury.
Lippincott Williams & Wilkins