The role of recipient derived interleukin-17A in a murine orthotopic lung transplant model of restrictive chronic lung allograft dysfunction
Y Yamada, E Vandermeulen, T Heigl, J Somers… - Transplant …, 2016 - Elsevier
The single most important cause of late mortality after lung transplantation is chronic lung
allograft dysfunction (CLAD). However, the pathological development of CLAD was not as
simple as previously presumed and subclassification phenotypes, bronchiolitis obliterans
syndrome (BOS) and restrictive CLAD (rCLAD), have been introduced. We want to re-
investigate how CLAD manifests in the murine orthotopic lung transplant model and
investigate the role of interleukin 17A (IL-17A) within this model. Orthotopic LTx was …
allograft dysfunction (CLAD). However, the pathological development of CLAD was not as
simple as previously presumed and subclassification phenotypes, bronchiolitis obliterans
syndrome (BOS) and restrictive CLAD (rCLAD), have been introduced. We want to re-
investigate how CLAD manifests in the murine orthotopic lung transplant model and
investigate the role of interleukin 17A (IL-17A) within this model. Orthotopic LTx was …