Implications for human leukocyte antigen antibodies after lung transplantation: a 10-year experience in 441 patients

LD Snyder, Z Wang, DF Chen, NL Reinsmoen… - Chest, 2013 - Elsevier
Background Long-term survival after lung transplant is limited by the development of chronic
and progressive airflow obstruction, a condition known as bronchiolitis obliterans syndrome
(BOS). While prior studies strongly implicate cellular rejection as a strong risk factor for BOS,
less is known about the clinical significance of human leukocyte antigen (HLA) antibodies
and donor HLA-specific antibodies in long-term outcomes. Methods A single-center cohort of
441 lung transplant recipients, spanning a 10-year period, was prospectively screened for …