[HTML][HTML] Human Kruppel-like factor 5 is a target of the E3 ubiquitin ligase WWP1 for proteolysis in epithelial cells
The transcription factor KLF5 plays an important role in human carcinogenesis. In epithelial
cells, the KLF5 protein is tightly regulated by the ubiquitin-proteasome pathway. To better
understand the mechanisms for the regulation of KLF5 protein, we identified and
characterized an E3 ubiquitin ligase for KLF5, ie WWP1. We found that WWP1 formed a
protein complex with KLF5 in vivo and in vitro. Furthermore, WWP1 mediated the
ubiquitination and degradation of KLF5, and the catalytic cysteine residue of WWP1 is …
cells, the KLF5 protein is tightly regulated by the ubiquitin-proteasome pathway. To better
understand the mechanisms for the regulation of KLF5 protein, we identified and
characterized an E3 ubiquitin ligase for KLF5, ie WWP1. We found that WWP1 formed a
protein complex with KLF5 in vivo and in vitro. Furthermore, WWP1 mediated the
ubiquitination and degradation of KLF5, and the catalytic cysteine residue of WWP1 is …