[HTML][HTML] Differential activation of cultured neonatal cardiomyocytes by plasmalemmal versus intracellular G protein-coupled receptor 55

J Yu, E Deliu, XQ Zhang, NE Hoffman, RL Carter… - Journal of Biological …, 2013 - ASBMB
The L-α-lysophosphatidylinositol (LPI)-sensitive receptor GPR55 is coupled to Ca 2+
signaling. Low levels of GPR55 expression in the heart have been reported. Similar to other
G protein-coupled receptors involved in cardiac function, GPR55 may be expressed both at
the sarcolemma and intracellularly. Thus, to explore the role of GPR55 in cardiomyocytes,
we used calcium and voltage imaging and extracellular administration or intracellular
microinjection of GPR55 ligands. We provide the first evidence that, in cultured neonatal …