Targeting CB2-GPR55 receptor heteromers modulates cancer cell signaling
The G protein-coupled receptors CB 2 (CB 2 R) and GPR55 are overexpressed in cancer
cells and human tumors. Because a modulation of GPR55 activity by cannabinoids has
been suggested, we analyzed whether this receptor participates in cannabinoid effects on
cancer cells. Here we show that CB 2 R and GPR55 form heteromers in cancer cells, that
these structures possess unique signaling properties, and that modulation of these
heteromers can modify the antitumoral activity of cannabinoids in vivo. These findings unveil …
cells and human tumors. Because a modulation of GPR55 activity by cannabinoids has
been suggested, we analyzed whether this receptor participates in cannabinoid effects on
cancer cells. Here we show that CB 2 R and GPR55 form heteromers in cancer cells, that
these structures possess unique signaling properties, and that modulation of these
heteromers can modify the antitumoral activity of cannabinoids in vivo. These findings unveil …
