[HTML][HTML] Anandamide exerts its antiproliferative actions on cholangiocarcinoma by activation of the GPR55 receptor
L Huang, JC Ramirez, GA Frampton, LE Golden… - Laboratory …, 2011 - Elsevier
Cholangiocarcinomas are devastating cancers of biliary origin with limited treatment options.
It has previously been shown that the endocannabinoid anandamide exerts antiproliferative
effects on cholangiocarcinoma independent of any known cannabinoid receptors, and by
the stabilization of lipid rafts, thereby allowing the recruitment and activation of the Fas death
receptor complex. Recently, GPR55 was identified as a putative cannabinoid receptor;
therefore, the role of GPR55 in the antiproliferative effects of anandamide was evaluated …
It has previously been shown that the endocannabinoid anandamide exerts antiproliferative
effects on cholangiocarcinoma independent of any known cannabinoid receptors, and by
the stabilization of lipid rafts, thereby allowing the recruitment and activation of the Fas death
receptor complex. Recently, GPR55 was identified as a putative cannabinoid receptor;
therefore, the role of GPR55 in the antiproliferative effects of anandamide was evaluated …