The putative cannabinoid receptor GPR55 plays a role in mechanical hyperalgesia associated with inflammatory and neuropathic pain
PC Staton, JP Hatcher, DJ Walker, AD Morrison… - Pain, 2008 - Elsevier
It has been postulated that the G protein-coupled receptor, GPR55, is a third cannabinoid
receptor. Given that the ligands at the CB1 and CB2 receptors are effective analgesic and
anti-inflammatory agents, the role of GPR55 in hyperalgesia associated with inflammatory
and neuropathic pain has been investigated. As there are no well-validated GPR55 tool
compounds, a GPR55 knockout (GPR55−/−) mouse line was generated and fully
backcrossed onto the C57BL/6 strain. General phenotypic analysis of GPR55−/− mice …
receptor. Given that the ligands at the CB1 and CB2 receptors are effective analgesic and
anti-inflammatory agents, the role of GPR55 in hyperalgesia associated with inflammatory
and neuropathic pain has been investigated. As there are no well-validated GPR55 tool
compounds, a GPR55 knockout (GPR55−/−) mouse line was generated and fully
backcrossed onto the C57BL/6 strain. General phenotypic analysis of GPR55−/− mice …
