Formation of lysophosphatidylinositol in platelets stimulated with thrombin or ionophore A23187.
MM Billah, EG Lapetina - Journal of Biological Chemistry, 1982 - jbc.org
In stimulated platelets phosphatidylinositol is degraded by a phosphatidylinositol-specific
phospholipase C to 1, 2-diacylglycerol which is then phosphorylated to phosphatidic acid.
Thrombin stimulation of horse and human platelets prelabeled with [32P] orthophosphate
induces the formation of [32P] lysophosphatidylinositol, suggesting that phosphatidylinositol
is also degraded by a phospholipase of A type activity. Stimulation of platelets prelabeled
with 32P or with 32P plus [3H] inositol produces a lysophosphatidylinositol which has a 32P …
phospholipase C to 1, 2-diacylglycerol which is then phosphorylated to phosphatidic acid.
Thrombin stimulation of horse and human platelets prelabeled with [32P] orthophosphate
induces the formation of [32P] lysophosphatidylinositol, suggesting that phosphatidylinositol
is also degraded by a phospholipase of A type activity. Stimulation of platelets prelabeled
with 32P or with 32P plus [3H] inositol produces a lysophosphatidylinositol which has a 32P …
