Role of the lysophosphatidylinositol/GPR55 axis in cancer
M Falasca, R Ferro - Advances in biological regulation, 2016 - Elsevier
Lysophosphatidylinositol (LPI) is a well-known bioactive lipid that is able to activate
signalling cascades relevant to cell proliferation, migration, survival and tumourigenesis. It is
well-established that the G protein-coupled receptor 55 (GPR55) is the specific receptor for
LPI. Several investigations have demonstrated that the signalling pathways activated by LPI
through its receptor GPR55 play a pivotal role in different cancer type. This review focuses
on the role of the LPI/GPR55 axis, in particular with regards to its pharmacological potential …
signalling cascades relevant to cell proliferation, migration, survival and tumourigenesis. It is
well-established that the G protein-coupled receptor 55 (GPR55) is the specific receptor for
LPI. Several investigations have demonstrated that the signalling pathways activated by LPI
through its receptor GPR55 play a pivotal role in different cancer type. This review focuses
on the role of the LPI/GPR55 axis, in particular with regards to its pharmacological potential …