[HTML][HTML] Spatiotemporal interplay of severe acute respiratory syndrome coronavirus and respiratory mucosal cells drives viral dissemination in rhesus macaques
L Liu, Q Wei, K Nishiura, J Peng, H Wang, C Midkiff… - Mucosal …, 2016 - Elsevier
Innate immune responses have a critical role in the control of early virus replication and
dissemination. It remains unknown, however, how severe acute respiratory syndrome
coronavirus (SARS-CoV) evades respiratory innate immunity to establish a systemic
infection. Here we show in Chinese macaques that SARS-CoV traversed the mucosa
through the respiratory tract within 2 days, resulting in extensive mucosal infiltration by T
cells, MAC387+, and CD163+ monocytes/macrophages followed by limited viral replication …
dissemination. It remains unknown, however, how severe acute respiratory syndrome
coronavirus (SARS-CoV) evades respiratory innate immunity to establish a systemic
infection. Here we show in Chinese macaques that SARS-CoV traversed the mucosa
through the respiratory tract within 2 days, resulting in extensive mucosal infiltration by T
cells, MAC387+, and CD163+ monocytes/macrophages followed by limited viral replication …
