[HTML][HTML] The proapoptotic F-box protein Fbxl7 regulates mitochondrial function by mediating the ubiquitylation and proteasomal degradation of survivin
Fbxl7, a component of the Skp1· Cul1· F-box protein type ubiquitin E3 ligase, regulates
mitotic cell cycle progression. Here we demonstrate that overexpression of Fbxl7 in lung
epithelia decreases the protein abundance of survivin, a member of the inhibitor of
apoptosis family. Fbxl7 mediates polyubiquitylation and proteasomal degradation of survivin
by interacting with Glu-126 within its carboxyl-terminal α helix. Furthermore, both Lys-90 and
Lys-91 within survivin serve as ubiquitin acceptor sites. Ectopically expressed Fbxl7 impairs …
mitotic cell cycle progression. Here we demonstrate that overexpression of Fbxl7 in lung
epithelia decreases the protein abundance of survivin, a member of the inhibitor of
apoptosis family. Fbxl7 mediates polyubiquitylation and proteasomal degradation of survivin
by interacting with Glu-126 within its carboxyl-terminal α helix. Furthermore, both Lys-90 and
Lys-91 within survivin serve as ubiquitin acceptor sites. Ectopically expressed Fbxl7 impairs …