Energetics, epigenetics, mitochondrial genetics

DC Wallace, W Fan - Mitochondrion, 2010 - Elsevier
The epigenome has been hypothesized to provide the interface between the environment
and the nuclear DNA (nDNA) genes. Key factors in the environment are the availability of
calories and demands on the organism's energetic capacity. Energy is funneled through
glycolysis and mitochondrial oxidative phosphorylation (OXPHOS), the cellular bioenergetic
systems. Since there are thousands of bioenergetic genes dispersed across the
chromosomes and mitochondrial DNA (mtDNA), both cis and trans regulation of the nDNA …