[HTML][HTML] Effects of omega-3 and-6 fatty acids on Mycobacterium tuberculosis in macrophages and in mice
L Jordao, A Lengeling, Y Bordat, F Boudou… - Microbes and …, 2008 - Elsevier
We recently showed that treatment of macrophages prior to Mycobacterium tuberculosis
infection with the pro-inflammatory omega-6 lipid, arachidonic acid (AA) enhanced bacterial
killing whereas the anti-inflammatory, omega-3 lipid eicosapentaenoic acid (EPA) stimulated
bacterial growth. Here we tested if these effects were depending on when lipids were added
to macrophages: before or during Mycobacterium smegmatis or M. tuberculosis infection.
Collectively, our data suggested that a high omega-6 diet might be beneficial against …
infection with the pro-inflammatory omega-6 lipid, arachidonic acid (AA) enhanced bacterial
killing whereas the anti-inflammatory, omega-3 lipid eicosapentaenoic acid (EPA) stimulated
bacterial growth. Here we tested if these effects were depending on when lipids were added
to macrophages: before or during Mycobacterium smegmatis or M. tuberculosis infection.
Collectively, our data suggested that a high omega-6 diet might be beneficial against …