Myelin ingestion by macrophages promotes their motility and capacity to recruit myeloid cells
M van Zwam, AF Wierenga-Wolf, MJ Melief… - Journal of …, 2010 - Elsevier
Myelin-laden macrophages reside within the CNS, the CSF and in the CNS-draining lymph
nodes during MS and EAE, suggesting migration of these macrophages between these
compartments and interaction with other cells. Since chemokines and their receptors are
pivotal for leukocyte trafficking, we addressed whether myelin ingestion affects chemotaxis
of mouse macrophages in vitro. Myelin ingestion enhanced expression of CCR7 and
CXCR3 on macrophages and migration towards CCL21 and CXCL10. Furthermore, myelin …
nodes during MS and EAE, suggesting migration of these macrophages between these
compartments and interaction with other cells. Since chemokines and their receptors are
pivotal for leukocyte trafficking, we addressed whether myelin ingestion affects chemotaxis
of mouse macrophages in vitro. Myelin ingestion enhanced expression of CCR7 and
CXCR3 on macrophages and migration towards CCL21 and CXCL10. Furthermore, myelin …