High immunosuppressive burden in advanced hepatocellular carcinoma patients: Can effector functions be restored?
AA Lugade, S Kalathil, A Miller, R Iyer… - …, 2013 - Taylor & Francis
AA Lugade, S Kalathil, A Miller, R Iyer, Y Thanavala
Oncoimmunology, 2013•Taylor & FrancisThe accumulation of immunosuppressive cells and exhausted effector T cells highlight an
important immune dysfunction in advanced stage hepatocellular carcinoma (HCC) patients.
These cells significantly hamper the efficacy immunotherapies and facilitate HCC
progression. We have recently demonstrated that the multipronged depletion of
immunosuppressive cells potentially restores effector T-cell function in HCC.
important immune dysfunction in advanced stage hepatocellular carcinoma (HCC) patients.
These cells significantly hamper the efficacy immunotherapies and facilitate HCC
progression. We have recently demonstrated that the multipronged depletion of
immunosuppressive cells potentially restores effector T-cell function in HCC.
The accumulation of immunosuppressive cells and exhausted effector T cells highlight an important immune dysfunction in advanced stage hepatocellular carcinoma (HCC) patients. These cells significantly hamper the efficacy immunotherapies and facilitate HCC progression. We have recently demonstrated that the multipronged depletion of immunosuppressive cells potentially restores effector T-cell function in HCC.
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