Noncoronary cardiac abnormalities are associated with coronary artery dilation and with laboratory inflammatory markers in acute Kawasaki disease

BF Printz, LA Sleeper, JW Newburger… - Journal of the American …, 2011 - jacc.org
BF Printz, LA Sleeper, JW Newburger, LLA Minich, T Bradley, MS Cohen, D Frank, JS Li
Journal of the American College of Cardiology, 2011jacc.org
Objectives: We explored the association of noncoronary cardiac abnormalities with coronary
artery dilation and with laboratory inflammatory markers early after Kawasaki disease (KD)
diagnosis. Background: Left ventricular (LV) dysfunction, mitral regurgitation (MR), and aortic
root dilation occur early after diagnosis; their associations with coronary artery dilation and
inflammatory markers have not been well-described. Methods: Centrally interpreted
echocardiograms were obtained at KD diagnosis and 1 and 5 weeks after diagnosis on 198 …
Objectives
We explored the association of noncoronary cardiac abnormalities with coronary artery dilation and with laboratory inflammatory markers early after Kawasaki disease (KD) diagnosis.
Background
Left ventricular (LV) dysfunction, mitral regurgitation (MR), and aortic root dilation occur early after diagnosis; their associations with coronary artery dilation and inflammatory markers have not been well-described.
Methods
Centrally interpreted echocardiograms were obtained at KD diagnosis and 1 and 5 weeks after diagnosis on 198 subjects in the National Institutes of Health-sponsored Pediatric Heart Network KD pulsed steroid trial. Regression models were constructed to investigate the relationships among early LV dysfunction, MR, and aortic root dilation with coronary artery dilation and laboratory inflammatory markers.
Results
At diagnosis, LV systolic dysfunction was present in 20% of subjects and was associated with coronary artery dilation, seen in 29% (p = 0.004). Although LV dysfunction improved rapidly, LV dysfunction at diagnosis predicted greater odds of coronary artery dilation at 1 and 5 weeks after diagnosis (5-week odds ratio: 2.7, 95% confidence interval: 1.2 to 6.3). At diagnosis, MR was present in 27% of subjects and aortic root dilation was present in 8%; each was associated with larger coronary artery size at diagnosis. Left ventricular dysfunction was associated with higher erythrocyte sedimentation rate and, at diagnosis only, lower serum albumin; MR was associated with higher erythrocyte sedimentation rate and lower albumin at all times. Aortic root size had little association with inflammatory markers.
Conclusions
Noncoronary cardiac abnormalities are associated with coronary artery dilation and laboratory evidence of inflammation in the first 5 weeks after KD, suggesting a shared inflammatory mechanism. (Trial of Pulse Steroid Therapy in Kawasaki Disease [A Trial Conducted by the Pediatric Heart Network]; NCT00132080)
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