[HTML][HTML] The many faces of calmodulin in cell proliferation, programmed cell death, autophagy, and cancer

MW Berchtold, A Villalobo - Biochimica et Biophysica Acta (BBA)-Molecular …, 2014 - Elsevier
Biochimica et Biophysica Acta (BBA)-Molecular Cell Research, 2014Elsevier
Calmodulin (CaM) is a ubiquitous Ca 2+ receptor protein mediating a large number of
signaling processes in all eukaryotic cells. CaM plays a central role in regulating a myriad of
cellular functions via interaction with multiple target proteins. This review focuses on the
action of CaM and CaM-dependent signaling systems in the control of vertebrate cell
proliferation, programmed cell death and autophagy. The significance of CaM and
interconnected CaM-regulated systems for the physiology of cancer cells including tumor …
Abstract
Calmodulin (CaM) is a ubiquitous Ca2 + receptor protein mediating a large number of signaling processes in all eukaryotic cells. CaM plays a central role in regulating a myriad of cellular functions via interaction with multiple target proteins. This review focuses on the action of CaM and CaM-dependent signaling systems in the control of vertebrate cell proliferation, programmed cell death and autophagy. The significance of CaM and interconnected CaM-regulated systems for the physiology of cancer cells including tumor stem cells, and processes required for tumor progression such as growth, tumor-associated angiogenesis and metastasis are highlighted. Furthermore, the potential targeting of CaM-dependent signaling processes for therapeutic use is discussed.
Elsevier