[HTML][HTML] Vascular endothelial growth factor stimulates tyrosine phosphorylation and recruitment to new focal adhesions of focal adhesion kinase and paxillin in …
H Abedi, I Zachary - Journal of Biological Chemistry, 1997 - ASBMB
Vascular endothelial growth factor (VEGF) stimulated the tyrosine phosphorylation of
multiple components in confluent human umbilical vein endothelial cells (HUVECs)
including bands of M r 205,000, corresponding to the VEGF receptors Flt-1 and KDR, and M
r 145,000, 120,000, 97,000, and 65,000–70,000. VEGF caused a striking and transient
increase in mitogen-activated protein (MAP) kinase activity and stimulated phospholipase C-
γ tyrosine phosphorylation, but it had no effect on phosphatidylinositol 3′-kinase activity …
multiple components in confluent human umbilical vein endothelial cells (HUVECs)
including bands of M r 205,000, corresponding to the VEGF receptors Flt-1 and KDR, and M
r 145,000, 120,000, 97,000, and 65,000–70,000. VEGF caused a striking and transient
increase in mitogen-activated protein (MAP) kinase activity and stimulated phospholipase C-
γ tyrosine phosphorylation, but it had no effect on phosphatidylinositol 3′-kinase activity …