[HTML][HTML] Lipid absorption defects in intestine-specific microsomal triglyceride transfer protein and ATP-binding cassette transporter A1-deficient mice
We have previously described apolipoprotein B (apoB)-dependent and-independent
cholesterol absorption pathways and the role of microsomal triglyceride transfer protein
(MTP) and ATP-binding cassette transporter A1 (ABCA1) in these pathways. To assess the
contribution of these pathways to cholesterol absorption and to determine whether there are
other pathways, we generated mice that lack MTP and ABCA1, individually and in
combination, in the intestine. Intestinal deletions of Mttp and Abca1 decreased plasma …
cholesterol absorption pathways and the role of microsomal triglyceride transfer protein
(MTP) and ATP-binding cassette transporter A1 (ABCA1) in these pathways. To assess the
contribution of these pathways to cholesterol absorption and to determine whether there are
other pathways, we generated mice that lack MTP and ABCA1, individually and in
combination, in the intestine. Intestinal deletions of Mttp and Abca1 decreased plasma …