Background & Aims The most prescribed non-nucleoside reverse transcriptase inhibitor,
efavirenz, has been associated with elevated risk of dyslipidemia and hepatic steatosis in
HIV-infected patients but the underlying mechanisms remain elusive. Herein, we
investigated the role of pregnane X receptor (PXR) in mediating the adverse effects of
efavirenz on lipid homeostasis. Methods Cell-based reporter assays, primary cell culture,
and multiple mouse models including conditional knockout and humanized mice were …