[HTML][HTML] Activation of PXR induces hypercholesterolemia in wild-type and accelerates atherosclerosis in apoE deficient mice [S]

C Zhou, N King, KY Chen, JL Breslow - Journal of lipid research, 2009 - ASBMB
The nuclear hormone receptor pregnane X receptor (PXR; also called SXR) functions as a
xenobiotic sensor to coordinately regulate xenobiotic metabolism via transcriptional
regulation of xenobiotic-detoxifying enzymes and transporters. Although many clinically
relevant PXR ligands have been shown to affect cholesterol levels, the role of PXR in
cholesterol homeostasis and atherosclerosis has not been thoroughly investigated. Here,
we report that activation of PXR by feeding the PXR agonist pregnenolone 16α-carbonitrile …