The DNA-dependent protein kinase: A multifunctional protein kinase with roles in DNA double strand break repair and mitosis
N Jette, SP Lees-Miller - Progress in biophysics and molecular biology, 2015 - Elsevier
Progress in biophysics and molecular biology, 2015•Elsevier
The DNA-dependent protein kinase (DNA-PK) is a serine/threonine protein kinase
composed of a large catalytic subunit (DNA-PKcs) and the Ku70/80 heterodimer. Over the
past two decades, significant progress has been made in elucidating the role of DNA-PK in
non-homologous end joining (NHEJ), the major pathway for repair of ionizing radiation-
induced DNA double strand breaks in human cells and recently, additional roles for DNA-PK
have been reported. In this review, we will describe the biochemistry, structure and function …
composed of a large catalytic subunit (DNA-PKcs) and the Ku70/80 heterodimer. Over the
past two decades, significant progress has been made in elucidating the role of DNA-PK in
non-homologous end joining (NHEJ), the major pathway for repair of ionizing radiation-
induced DNA double strand breaks in human cells and recently, additional roles for DNA-PK
have been reported. In this review, we will describe the biochemistry, structure and function …
Abstract
The DNA-dependent protein kinase (DNA-PK) is a serine/threonine protein kinase composed of a large catalytic subunit (DNA-PKcs) and the Ku70/80 heterodimer. Over the past two decades, significant progress has been made in elucidating the role of DNA-PK in non-homologous end joining (NHEJ), the major pathway for repair of ionizing radiation-induced DNA double strand breaks in human cells and recently, additional roles for DNA-PK have been reported. In this review, we will describe the biochemistry, structure and function of DNA-PK, its roles in DNA double strand break repair and its newly described roles in mitosis and other cellular processes.
Elsevier