Growth hormone and cancer: an update on progress
Current Opinion in Endocrinology, Diabetes and Obesity, 2013•journals.lww.com
Substantial evidence suggests the GH/insulin-like growth factor-1 axis initiates and
promotes progression of cancer. However, important questions remain unanswered
regarding the therapeutic utility of GH or GHR antagonism in cancer. Further clinical studies
regarding the clinical association of GH expression with human malignancies and
translational studies investigating GHR antagonism in animal models of human cancer are
critical.
promotes progression of cancer. However, important questions remain unanswered
regarding the therapeutic utility of GH or GHR antagonism in cancer. Further clinical studies
regarding the clinical association of GH expression with human malignancies and
translational studies investigating GHR antagonism in animal models of human cancer are
critical.
Summary
Substantial evidence suggests the GH/insulin-like growth factor-1 axis initiates and promotes progression of cancer. However, important questions remain unanswered regarding the therapeutic utility of GH or GHR antagonism in cancer. Further clinical studies regarding the clinical association of GH expression with human malignancies and translational studies investigating GHR antagonism in animal models of human cancer are critical.
Lippincott Williams & Wilkins