Multiple mechanisms of growth hormone-regulated gene transcription

TI Ceseña, TX Cui, G Piwien-Pilipuk, J Kaplani… - Molecular genetics and …, 2007 - Elsevier
Diverse physiological actions of growth hormone (GH) are mediated by changes in gene
transcription. Transcription can be regulated at several levels, including post-translational
modification of transcription factors, and formation of multiprotein complexes involving
transcription factors, co-regulators and additional nuclear proteins; these serve as targets for
regulation by hormones and signaling pathways. Evidence that GH regulates transcription at
multiple levels is exemplified by analysis of the proto-oncogene c-fos. Among the GH …