AKI with incomplete epithelial repair is a major contributor to CKD characterized by
tubulointerstitial fibrosis. Injury–induced epithelial secretion of profibrotic factors is
hypothesized to underlie this link, but the identity of these factors and whether epithelial
injury is required remain undefined. We previously showed that activation of the canonical
Wnt signaling pathway in interstitial pericytes cell autonomously drives myofibroblast
activation in vivo. Here, we show that inhibition of canonical Wnt signaling also substantially …