Effect of mycophenolate mofetil therapy on lymphocyte activation in heart transplant recipients
G Weigel, A Griesmacher, A Karimi… - The Journal of heart and …, 2002 - Elsevier
BACKGROUND:: Mycophenolic acid is reported to provide effective immunosuppression by
inhibiting inosine monophosphate dehydrogenase. In an attempt to monitor the effects of
therapy with mycophenolate mofetil, we measured the expression of the activation markers
CD25, CD38, CD69 and HLA-DR on lymphocytes of patients after heart transplantation.
METHODS:: Thirty-six patients enrolled in the study were randomly assigned to one of two
groups. Patients in the control group (n= 15) received cyclosporine, azathioprine and …
inhibiting inosine monophosphate dehydrogenase. In an attempt to monitor the effects of
therapy with mycophenolate mofetil, we measured the expression of the activation markers
CD25, CD38, CD69 and HLA-DR on lymphocytes of patients after heart transplantation.
METHODS:: Thirty-six patients enrolled in the study were randomly assigned to one of two
groups. Patients in the control group (n= 15) received cyclosporine, azathioprine and …