Immunosuppressive drugs on inducing Ag-specific CD4+ CD25+ Foxp3+ Treg cells during immune response in vivo
T Wu, L Zhang, K Xu, C Sun, T Lei, J Peng, G Liu… - Transplant …, 2012 - Elsevier
A variety of immunosuppressive drugs are currently used in patients with allo-grafts or
autoimmune diseases. Though the effects of rapamycin (RPM) and other
immunosuppressant on the CD4+ CD25+ Foxp3+ T regulatory cells (Tregs) were studied,
their impact on Ag-specific Tregs during immune response was not well defined. In our
studies, we adoptively transferred TCR-transgenic CD4+ KJ1-26+ T cells, CD4+ KJ1-26+
CD25− naïve T cells or CD4+ KJ1-26+ CD25+ Tregs into syngeneic BALB/c mice. 24h later …
autoimmune diseases. Though the effects of rapamycin (RPM) and other
immunosuppressant on the CD4+ CD25+ Foxp3+ T regulatory cells (Tregs) were studied,
their impact on Ag-specific Tregs during immune response was not well defined. In our
studies, we adoptively transferred TCR-transgenic CD4+ KJ1-26+ T cells, CD4+ KJ1-26+
CD25− naïve T cells or CD4+ KJ1-26+ CD25+ Tregs into syngeneic BALB/c mice. 24h later …
