[HTML][HTML] Hydrogel coated mesh decreases tissue reaction resulting from polypropylene mesh implant: implication in hernia repair

DP Poppas, JJ Sung, CM Magro, J Chen, JP Toyohara… - Hernia, 2016 - Springer
DP Poppas, JJ Sung, CM Magro, J Chen, JP Toyohara, BJ Ramshaw, D Felsen
Hernia, 2016Springer
Purpose Use of polypropylene mesh (PPM) in hernia repair is associated with tissue
reactivity. We examined, in a rat model, a novel non-biodegradable hydrogel coated PPM
which may allow for decreased inflammation and a decreased foreign body reaction.
Methods Through a dorsal midline incision, a 2 cm× 2 cm section of PPM (either coated or
uncoated) was placed on the fascial surface 1.5 cm from the incision on the dorsal wall of
Sprague–Dawley rats. At 2 and 12 weeks after placement, the PPM and surrounding tissue …
Purpose
Use of polypropylene mesh (PPM) in hernia repair is associated with tissue reactivity. We examined, in a rat model, a novel non-biodegradable hydrogel coated PPM which may allow for decreased inflammation and a decreased foreign body reaction.
Methods
Through a dorsal midline incision, a 2 cm × 2 cm section of PPM (either coated or uncoated) was placed on the fascial surface 1.5 cm from the incision on the dorsal wall of Sprague–Dawley rats. At 2 and 12 weeks after placement, the PPM and surrounding tissue were harvested. A board-certified dermatopathologist examined H&E stained slides for fibrosis and foreign body reaction. In addition, tissues were stained for apoptotic cells, oxidative damage, macrophages, fibroblasts, neovascularization and metalloproteases.
Results
At 2 and 12 weeks, there was a greater than 95 % decrease in foreign body giant cells in coated PPM samples compared to uncoated; fibrosis was decreased by 50 %. At 2 and 12 weeks, oxidative damage, fibroblast accumulation, apoptosis and macrophages were significantly decreased in coated PPM samples compared to uncoated PPM.
Conclusion
These results demonstrate that a non-biodegradable hydrogel coating of PPM led to significant reduction in foreign body reaction, oxidative stress and apoptosis compared to uncoated PPM in vivo, and suggest that this coating could be clinically useful in hernia repair.
Springer