NF-κB in renal inflammation
AB Sanz, MD Sanchez-Niņo, AM Ramos… - Journal of the …, 2010 - journals.lww.com
The NF-κB family of transcription factors regulates the induction and resolution of
inflammation. Two main pathways, classical and alternative, control the nuclear
translocation of NF-κB. Classical NF-κB activation is usually a rapid and transient response
to a wide range of stimuli whose main effector is RelA/p50. The alternative NF-κB pathway is
a more delayed response to a smaller range of stimuli resulting in DNA binding of RelB/p52
complexes. Additional complexity in this system involves the posttranslational modification of …
inflammation. Two main pathways, classical and alternative, control the nuclear
translocation of NF-κB. Classical NF-κB activation is usually a rapid and transient response
to a wide range of stimuli whose main effector is RelA/p50. The alternative NF-κB pathway is
a more delayed response to a smaller range of stimuli resulting in DNA binding of RelB/p52
complexes. Additional complexity in this system involves the posttranslational modification of …