[HTML][HTML] Hypoxia-inducible factor 1 and VEGF upregulate CXCR4 in glioblastoma: implications for angiogenesis and glioma cell invasion
D Zagzag, Y Lukyanov, L Lan, MA Ali, M Esencay… - Laboratory …, 2006 - Elsevier
Hypoxia and hypoxia-inducible factor-1 (HIF-1) play a critical role in glioblastoma multiforme
(GBMs). CXCR4 is involved in angiogenesis and is upregulated by HIF-1α. CXCR4 is a
chemokine receptor for stromal cell-derived factor-1 (SDF-1) α, also known as CXCL12. We
hypothesized that CXCR4 would be upregulated by hypoxia in GBMs. First, we investigated
the expression of HIF-1α and CXCR4 in GBMs. CXCR4 was consistently found colocalized
with HIF-1α expression in pseudopalisading glioma cells around areas of necrosis. In …
(GBMs). CXCR4 is involved in angiogenesis and is upregulated by HIF-1α. CXCR4 is a
chemokine receptor for stromal cell-derived factor-1 (SDF-1) α, also known as CXCL12. We
hypothesized that CXCR4 would be upregulated by hypoxia in GBMs. First, we investigated
the expression of HIF-1α and CXCR4 in GBMs. CXCR4 was consistently found colocalized
with HIF-1α expression in pseudopalisading glioma cells around areas of necrosis. In …
