Sepsis definitions: a work in progress
JC Marshall - Critical Care Clinics, 2018 - criticalcare.theclinics.com
The recognition that infection is a transmissible disease caused by the invasion of healthy
tissues by pathogenic microorganisms was a product of multiple scientific advances in the
nineteenth century. Over evolutionary history, however, the dynamic interactions between
microbes and their multicellular hosts have shaped the immune system and become
imprinted in the genome. The consequence is an enormously complex process, at once
fundamental to survival and one of the leading causes of death on the planet. 1 It follows that …
tissues by pathogenic microorganisms was a product of multiple scientific advances in the
nineteenth century. Over evolutionary history, however, the dynamic interactions between
microbes and their multicellular hosts have shaped the immune system and become
imprinted in the genome. The consequence is an enormously complex process, at once
fundamental to survival and one of the leading causes of death on the planet. 1 It follows that …