Objectives: Mesenchymal stromal cells are being investigated as a cell-based therapy for a
number of disease processes, with promising results in animal models of systemic
inflammation and sepsis. Studies are ongoing to determine ways to further improve the
therapeutic potential of mesenchymal stromal cells. A gas molecule that improves outcome
in experimental sepsis is carbon monoxide. We hypothesized that preconditioning of
mesenchymal stromal cells with carbon monoxide ex vivo would promote further therapeutic …