Mitochondrial DNA and toll-like receptor-9 are associated with mortality in critically ill patients
KA Krychtiuk, S Ruhittel, PJ Hohensinner… - Critical care …, 2015 - journals.lww.com
Objectives: Despite underlying pathologies leading to ICU admittance are heterogeneous,
many patients develop a systemic inflammatory response syndrome often in the absence of
microbial pathogens. Mitochondrial DNA that shows similarities to bacterial DNA may be
released after tissue damage and activates the innate immune system by binding to toll-like
receptor-9 on immune cells. The aim of this study was to analyze whether levels of
mitochondrial DNA are associated with 30-day survival and whether this predictive value is …
many patients develop a systemic inflammatory response syndrome often in the absence of
microbial pathogens. Mitochondrial DNA that shows similarities to bacterial DNA may be
released after tissue damage and activates the innate immune system by binding to toll-like
receptor-9 on immune cells. The aim of this study was to analyze whether levels of
mitochondrial DNA are associated with 30-day survival and whether this predictive value is …