[HTML][HTML] The curse of angiopoietin-2 in ARDS: on stranger TI (E) des
P Kümpers, A Lukasz - Critical Care, 2018 - Springer
P Kümpers, A Lukasz
Critical Care, 2018•SpringerPulmonary inflammation and vascular leakage are hallmarks of acute respiratory distress
syndrome (ARDS), a life-threatening condition, for which there is no specific pharmacologic
treatment. Recent literature suggests that leaky vessels in pulmonary infection and ARDS
may be mediated through dysregulation of a non-redundant endothelial control pathway, the
Tie2 receptor and its ligands, the angiopoietins. This Viewpoint summarizes results from cell-
based experiments, animal models and clinical studies underlining the potential of Tie2 …
syndrome (ARDS), a life-threatening condition, for which there is no specific pharmacologic
treatment. Recent literature suggests that leaky vessels in pulmonary infection and ARDS
may be mediated through dysregulation of a non-redundant endothelial control pathway, the
Tie2 receptor and its ligands, the angiopoietins. This Viewpoint summarizes results from cell-
based experiments, animal models and clinical studies underlining the potential of Tie2 …
Abstract
Pulmonary inflammation and vascular leakage are hallmarks of acute respiratory distress syndrome (ARDS), a life-threatening condition, for which there is no specific pharmacologic treatment.
Recent literature suggests that leaky vessels in pulmonary infection and ARDS may be mediated through dysregulation of a non-redundant endothelial control pathway, the Tie2 receptor and its ligands, the angiopoietins.
This Viewpoint summarizes results from cell-based experiments, animal models and clinical studies underlining the potential of Tie2 targeted interventions in reducing infection-mediated pulmonary hyperpermeability.
Springer