Summarizing differences in cumulative incidence functions

MJ Zhang, J Fine - Statistics in Medicine, 2008 - Wiley Online Library
MJ Zhang, J Fine
Statistics in Medicine, 2008Wiley Online Library
The cumulative incidence function is widely reported in competing risks studies, with group
differences assessed by an extension of the log‐rank test. However, simple, interpretable
summaries of group differences are not available. An adaptation of the proportional hazards
model to the cumulative incidence function is often employed, but the interpretation of the
hazard ratio may be somewhat awkward, unlike the usual survival set‐up. We propose
nonparametric inferences for general summary measures, which may be time‐varying, and …
Abstract
The cumulative incidence function is widely reported in competing risks studies, with group differences assessed by an extension of the log‐rank test. However, simple, interpretable summaries of group differences are not available. An adaptation of the proportional hazards model to the cumulative incidence function is often employed, but the interpretation of the hazard ratio may be somewhat awkward, unlike the usual survival set‐up. We propose nonparametric inferences for general summary measures, which may be time‐varying, and for time‐averaged versions of the measures. Theoretical justification is provided using counting process techniques. A real data example illustrates the practical utility of the methods. Copyright © 2008 John Wiley & Sons, Ltd.
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